解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The prenatal origins of heart disease in offspring have been established. However, research in species with developmental milestones comparable to humans is lacking, preventing translation of this knowledge to clinical contexts. Using sheep and chickens, two species with similar cardiovascular developmental milestones...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb1929
更新日期:2020-08-19 00:00:00
abstract::Maternal immune activation increases the risk of neurodevelopmental disorders. Elevated cytokines, such as interferon-γ (IFN-γ), in offspring's brains play a central role. IFN-γ activates an antiviral cellular state, limiting viral entry and replication. Moreover, IFN-γ is implicated in brain development. We tested th...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay9506
更新日期:2020-08-19 00:00:00
abstract::Chronic suppurative otitis media (CSOM) is a neglected pediatric disease affecting 330 million worldwide for which no new drugs have been introduced for over a decade. We developed a mouse model with utility in preclinical drug evaluation and antimicrobial discovery. Our model used immune-competent mice, tympanic memb...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc1828
更新日期:2020-08-14 00:00:00
abstract::Two-dimensional (2D) polymers hold great promise in the rational materials design tailored for next-generation applications. However, little is known about the grain boundaries in 2D polymers, not to mention their formation mechanisms and potential influences on the material's functionalities. Using aberration-correct...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb5976
更新日期:2020-08-14 00:00:00
abstract::Immunoglobulin heavy chain (IgH) genes are assembled by two sequential DNA rearrangement events that are initiated by recombination activating gene products (RAG) 1 and 2. Diversity (DH) gene segments rearrange first, followed by variable (VH) gene rearrangements. Here, we provide evidence that each rearrangement step...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz8850
更新日期:2020-08-14 00:00:00
abstract::Ciliary oscillations driven by molecular motors cause fluid motion at micron scale. Stable oscillations require a substantial source of dissipation to balance the energy input of motors. Conventionally, it stems from external fluid. We show, in contrast, that external fluid friction is negligible compared to internal ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb0503
更新日期:2020-08-12 00:00:00
abstract::We present an ab initio computational approach for the calculation of resonant Raman intensities, including both excitonic and nonadiabatic effects. Our diagrammatic approach, which we apply to two prototype, semiconducting layered materials, allows a detailed analysis of the impact of phonon-mediated exciton-exciton ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb5915
更新日期:2020-08-07 00:00:00
abstract::At a time of heightened anxiety surrounding immigration, state governments have increasingly sought to manage immigrant and refugee flows. Yet the factors that influence where immigrants choose to settle after arrival remain unclear. We bring evidence to this question by analyzing population-level data for refugees re...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb0295
更新日期:2020-08-07 00:00:00
abstract::Artificial liquid-repellent surfaces have attracted substantial scientific and industrial attention with a focus on creating functional topological features; however, the role of the underlying structures has been overlooked. Recent developments in micro-nanofabrication allow us now to construct a skin-muscle type sys...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba9721
更新日期:2020-08-05 00:00:00
abstract::In this study, we report the existence of a communication system among human smooth muscle cells that uses mechanical forces to frequency modulate long-range calcium waves. An important consequence of this mechanical signaling is that changes in stiffness of the underlying extracellular matrix can interfere with the f...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba1149
更新日期:2020-08-05 00:00:00
abstract::The outbreak of the highly contagious and deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), has posed a serious threat to public health across the globe, calling for the development of effective diagnostic markers and therapeutics. Here, we report a...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc1564
更新日期:2020-07-31 00:00:00
abstract::Ice-templating holds promise to become a powerful technique to construct high-performance bioinspired materials. Both ice nucleation and growth during the freezing process are crucial for the final architecture of the ice-templated material. However, effective ways to control these two very important factors are still...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb4712
更新日期:2020-07-31 00:00:00
abstract::Coastal vertical land motion affects projections of sea-level rise, and subsidence exacerbates flooding hazards. Along the ~1350-km California coastline, records of high-resolution vertical land motion rates are scarce due to sparse instrumentation, and hazards to coastal communities are underestimated. Here, we consi...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba4551
更新日期:2020-07-31 00:00:00
abstract::The ongoing conservation treatment program of the Ghent Altarpiece by Hubert and Jan Van Eyck, one of the iconic paintings of the west, has revealed that the designs of the paintings were changed several times, first by the original artists, and then during later restorations. The central motif, The Lamb of God, repre...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb3379
更新日期:2020-07-29 00:00:00
abstract::Using theory and experiments, we study the interface between two immiscible domains in a colloidal membrane composed of rigid rods of different lengths. Geometric considerations of rigid rod packing imply that a domain of sufficiently short rods in a background membrane of long rods is more susceptible to twist than t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba2331
更新日期:2020-07-29 00:00:00
abstract::Efforts at altering the dismal prognosis of pediatric midline gliomas focus on direct delivery strategies like convection-enhanced delivery (CED), where a cannula is implanted into tumor. Successful CED treatments require confirmation of tumor coverage, dosimetry, and longitudinal in vivo pharmacokinetic monitoring. T...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb4105
更新日期:2020-07-24 00:00:00
abstract::The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba1685
更新日期:2020-07-24 00:00:00
abstract::To achieve global elimination of hepatitis C virus (HCV), an effective cross-genotype vaccine is needed. The HCV envelope glycoprotein E2 is the main target for neutralizing antibodies (nAbs), which aid in HCV clearance and protection. E2 is structurally flexible and functions in engaging host receptors. Many nAbs bin...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb5642
更新日期:2020-07-24 00:00:00
abstract::Immotile cilia sense extracellular signals such as fluid flow, but whether Ca2+ plays a role in flow sensing has been unclear. Here, we examined the role of ciliary Ca2+ in the flow sensing that initiates the breaking of left-right (L-R) symmetry in the mouse embryo. Intraciliary and cytoplasmic Ca2+ transients were d...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba1195
更新日期:2020-07-22 00:00:00
abstract::Mobile genetic elements, such as human endogenous retroviruses (HERVs), produce proteins that regulate brain cell functions and synaptic transmission and have been implicated in the etiology of neurological and neurodevelopmental psychiatric disorders. However, the mechanisms by which these proteins of retroviral orig...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc0708
更新日期:2020-07-17 00:00:00
abstract::Here, an integrated cascade nanozyme with a formulation of Pt@PCN222-Mn is developed to eliminate excessive reactive oxygen species (ROS). This nanozyme mimics superoxide dismutase by incorporation of a Mn-[5,10,15,20-tetrakis(4-carboxyphenyl)porphyrinato]-based metal-organic framework compound capable of transforming...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb2695
更新日期:2020-07-17 00:00:00
abstract::Calcium homeostasis modulator 1 (CALHM1) is a voltage-gated ATP release channel that plays an important role in neural gustatory signaling and the pathogenesis of Alzheimer's disease. Here, we present a cryo-electron microscopy structure of full-length Ca2+-free CALHM1 from Danio rerio at an overall resolution of 3.1 ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba8161
更新日期:2020-07-17 00:00:00
abstract::Forecasting fields of oceanic phenomena has long been dependent on physical equation-based numerical models. The challenge is that many natural processes need to be considered for understanding complicated phenomena. In contrast, rules of the processes are already embedded in the time-series observation itself. Thus, ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba1482
更新日期:2020-07-15 00:00:00
abstract::Cues sent by political elites are known to influence public attitudes and behavior. Polarization in elite rhetoric may hinder effective responses to public health crises, when accurate information and rapid behavioral change can save lives. We examine polarization in cues sent to the public by current members of the U...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc2717
更新日期:2020-07-10 00:00:00
abstract::Interaction of swimming bacteria with flows controls their ability to explore complex environments, crucial to many societal and environmental challenges and relevant for microfluidic applications such as cell sorting. Combining experimental, numerical, and theoretical analysis, we present a comprehensive study of the...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb2012
更新日期:2020-07-10 00:00:00
abstract::The eastern oyster (Crassostrea virginica) is an important proxy for examining historical trajectories of coastal ecosystems. Measurement of ~40,000 oyster shells from archaeological sites along the Atlantic Coast of the United States provides a long-term record of oyster abundance and size. The data demonstrate incre...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba9652
更新日期:2020-07-10 00:00:00
abstract::We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity into microrobots entails many functional advantages beyond shape templating, such as the facile uptake of chemotherapeutic agents to achieve targeted drug deli...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba5855
更新日期:2020-07-08 00:00:00
abstract::User-interactive electronic skin is capable of spatially mapping touch via electric readout and providing visual output as a human-readable response. However, the high power consumption, complex structure, and high cost of user-interactive electronic skin are notable obstacles for practical application. Here, we repor...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba4294
更新日期:2020-07-08 00:00:00
abstract::[This corrects the article DOI: 10.1126/sciadv.aaz7822.]. ...
journal_title:Science advances
pub_type: 已发布勘误
doi:10.1126/sciadv.abd5216
更新日期:2020-07-08 00:00:00
abstract::Laser technology has developed and accelerated photo-induced nonequilibrium physics, from both the scientific and engineering viewpoints. Floquet engineering, i.e., controlling material properties and functionalities by time-periodic drives, is at the forefront of quantum physics of light-matter interaction. However, ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb4019
更新日期:2020-07-03 00:00:00
abstract::When a medium is rapidly heated and cooled, heat transfers to its surroundings as sound. A controllable source of this sound is realized through joule heating of thin, conductive films by an alternating current. Here, we show that arrays of these sources generate sound unique to this mechanism. From the sound alone, w...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb2752
更新日期:2020-07-01 00:00:00
abstract::Kv2.1 channels mediate cell death-enabling loss of cytosolic potassium in neurons following plasma membrane insertion at somatodendritic clusters. Overexpression of the carboxyl terminus (CT) of the cognate channel Kv2.2 is neuroprotective by disrupting Kv2.1 surface clusters. Here, we define a seven-amino acid declus...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz8110
更新日期:2020-07-01 00:00:00
abstract::Catalytic dehydrogenation and hydrogenation of amines and alcohols are important in the synthesis of fine chemicals. Despite several efficient homogeneous catalysts having been identified, highly active heterogeneous catalysts remain elusive, although they would meet an unmet need. Here, we show that bimetallic Pd-Au ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb3831
更新日期:2020-07-01 00:00:00
abstract::Cell lines are commonly used as cancer models. The tissue of origin provides context for understanding biological mechanisms and predicting therapy response. We therefore systematically examined whether cancer cell lines exhibit features matching the presumed cancer type of origin. Gene expression and DNA methylation ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba1862
更新日期:2020-07-01 00:00:00
abstract::Lake evaporation can influence basin-wide hydrological cycles and is an important factor in loss of water resources in endorheic lakes of the Tibetan Plateau. Because of the scarcity of data, published lake evaporation values are inconsistent, and their spatial distribution has never been reported. Presenting a plausi...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay8558
更新日期:2020-06-26 00:00:00
abstract::Transplanting beneficial bacteria to the gut microbiome can positively modulate the bacterial composition and remains of great interest in prevention and treatment. However, environmental assaults and rapid transit times in the gastrointestinal (GI) tract result in low oral bioavailability and limited intestinal colon...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb1952
更新日期:2020-06-24 00:00:00
abstract::Campylobacter coli and Campylobacter jejuni are responsible for 400 million to 500 million cases of enteric disease each year and represent the most common cause of bacterial gastroenteritis worldwide. Despite its global importance, Campylobacter vaccine development has been hampered by the lack of animal models that ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba4511
更新日期:2020-06-24 00:00:00
abstract::Microbial communities are self-controlled by repertoires of lethal agents, the antibiotics. In their turn, these antibiotics are regulated by bioscavengers that are selected in the course of evolution. Kinase-mediated phosphorylation represents one of the general strategies for the emergence of antibiotic resistance. ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz9861
更新日期:2020-06-24 00:00:00
abstract::Asymmetric interactions such as entropic (e.g., encoded by nonspherical shapes) or surface forces (e.g., encoded by patterned surface chemistry or DNA hybridization) provide access to functional states of colloidal matter, but versatile approaches for engineering asymmetric van der Waals interactions have the potentia...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb1327
更新日期:2020-06-19 00:00:00
abstract::Transplantation with donor corneas is the mainstay for treating corneal blindness, but a severe worldwide shortage necessitates the development of other treatment options. Corneal perforation from infection or inflammation is sealed with cyanoacrylate glue. However, the resulting cytotoxicity requires transplantation....
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba2187
更新日期:2020-06-17 00:00:00